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Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
《医学前沿(英文)》 2021年 第15卷 第4期 页码 644-648 doi: 10.1007/s11684-021-0847-4
关键词: neutralizing antibody antibody cocktail SARS-CoV-2 COVID-19 therapeutic strategy
Passive antibody therapy in emerging infectious diseases
《医学前沿(英文)》 doi: 10.1007/s11684-023-1021-y
关键词: SARS-CoV-2 COVID-19 convalescent plasma hyperimmunoglobulin neutralizing monoclonal antibodies
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Qian Wang, Linqi Zhang
《医学前沿(英文)》 2020年 第14卷 第1期 页码 30-42 doi: 10.1007/s11684-019-0721-9
关键词: HIV-1 broadly neutralizing antibodies Env conformational states vaccine design SOSIP
Human monoclonal antibodies as candidate therapeutics against emerging viruses
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 462-470 doi: 10.1007/s11684-017-0596-6
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses in vitro and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.
关键词: human monoclonal antibodies emerging infectious diseases SARS-CoV MERS-CoV Ebola virus
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen
《医学前沿(英文)》 2020年 第14卷 第6期 页码 746-751 doi: 10.1007/s11684-020-0822-5
Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying
《医学前沿(英文)》 2020年 第14卷 第2期 页码 149-159 doi: 10.1007/s11684-020-0764-y
关键词: influenza virus neutralizing antibody hemagglutinin globular head region trimeric interface
Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,
《工程(英文)》 doi: 10.1016/j.eng.2023.09.012
关键词: Poly- N -acetylglucosamine Conjugate vaccine Monoclonal antibody
Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA
《环境科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 409-416 doi: 10.1007/s11783-011-0349-8
关键词: cadmium hapten monoclonal antibody enzyme-linked immunosorbent assay (ELISA)
Synthesis of haptens and production of antibodies to bisphenol A
Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 366-372 doi: 10.15302/J-FASE-2017132
关键词: bisphenol A cross-reactivity hapten indirect competitive ELISA polyclonal antibody
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
《医学前沿(英文)》 2019年 第13卷 第1期 页码 83-93 doi: 10.1007/s11684-019-0682-z
Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%–85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause an S492R mutation in EGFR. However, little is known about the biological function of S492R EGFR. Therefore, we attempted to elucidate its biological function in CRC cells and explore new treatment strategies for this mutant form. Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR. Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225. mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations in vivo. Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR mutation.
关键词: S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy
Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第2期 页码 153-160 doi: 10.15302/J-FASE-2016097
From SARS to MERS: evidence and speculation
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 377-382 doi: 10.1007/s11684-016-0466-7
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths. Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.
关键词: middle east respiratory syndrome animal origin cross-species transmission monoclonal antibody
The biopharmaceutical industry in China: history and future perspectives
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 101-111 doi: 10.1007/s11684-012-0191-9
Biopharmaceuticals reflect the rapid progress achieved in modern biomedical research. This area has also become one of the main criteria for assessing the development level of biotechnology for a particular country. Although it has been only three decades since the first biopharmaceutical, recombinant human insulin, was licensed by the US Food and Drug Administration, the biopharmaceutical industry has become the fastest growing, most dynamic and technology-intensive sector in the biomedical field. Since the licensing of recombinant human interferon α1b in 1989, the biopharmaceutical industry in China has gone through initial developments and gradually entered a period of rapid growth. This paper provides an overview of the status and development trends of biopharmaceuticals in China, and compares them with those observed in developed countries.
关键词: biopharmaceuticals antibodies market trends diseases China national regulatory agency
Emerging immunological strategies: recent advances and future directions
《医学前沿(英文)》 2021年 第15卷 第6期 页码 805-828 doi: 10.1007/s11684-021-0886-x
关键词: cancer immunotherapy bispecific antibodies small molecules chimeric antigen receptor T therapy cancer vaccines
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
关键词: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
标题 作者 时间 类型 操作
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
期刊论文
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Qian Wang, Linqi Zhang
期刊论文
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen
期刊论文
Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in
Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying
期刊论文
Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial
Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,
期刊论文
Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples
Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA
期刊论文
Synthesis of haptens and production of antibodies to bisphenol A
Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN
期刊论文
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
期刊论文
Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive
Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG
期刊论文